RNAi-dependentPolycombrepression controls transposable elements inTetrahymena
نویسندگان
چکیده
منابع مشابه
Transposable genetic elements.
N atural selection, as Darwin rec ognized more than a centu ry ago, favors individuals and populations that acquire traits con ducive to survival and reproduction. The generation of biological variation, which gives rise to new and potentially advantageous combinations of genetic traits, is therefore a central requirement for the successful evolution of species in diverse and changing enviro...
متن کاملThe evolution of RNAi as a defence against viruses and transposable elements
RNA interference (RNAi) is an important defence against viruses and transposable elements (TEs). RNAi not only protects against viruses by degrading viral RNA, but hosts and viruses can also use RNAi to manipulate each other's gene expression, and hosts can encode microRNAs that target viral sequences. In response, viruses have evolved a myriad of adaptations to suppress and evade RNAi. RNAi ca...
متن کاملTransposable elements in Drosophila
Transposable elements (TEs) are mobile genetic elements that can mobilize within host genomes. As TEs comprise more than 40% of the human genome and are linked to numerous diseases, understanding their mechanisms of mobilization and regulation is important. Drosophila melanogaster is an ideal model organism for the study of eukaryotic TEs as its genome contains a diverse array of active TEs. TE...
متن کاملQuantitatively Increased Somatic Transposition of Transposable Elements in Drosophila Strains Compromised for RNAi
In Drosophila melanogaster, small RNAs homologous to transposable elements (TEs) are of two types: piRNA (piwi-interacting RNA) with size 23-29nt and siRNA (small interfering RNA) with size 19-22nt. The siRNA pathway is suggested to silence TE activities in somatic tissues based on TE expression profiles, but direct evidence of transposition is lacking. Here we developed an efficient FISH (fluo...
متن کاملGenetic Drift, Not Life History or RNAi, Determine Long-Term Evolution of Transposable Elements
Transposable elements (TEs) are a major source of genome variation across the branches of life. Although TEs may play an adaptive role in their host's genome, they are more often deleterious, and purifying selection is an important factor controlling their genomic loads. In contrast, life history, mating system, GC content, and RNAi pathways have been suggested to account for the disparity of T...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2019
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.320796.118